Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson's Disease
Journal of Movement Disorders
;
: 69-79, 2017.
Article
in English
| WPRIM
| ID: wpr-38089
ABSTRACT
Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease, is characterized by the loss of nigral dopaminergic neurons. PD leads to a series of clinical symptoms, including motor and non-motor disturbances. α-synuclein, the major component of Lewy bodies, is a hallmark lesion in PD. In this review, we concentrate on presenting the latest research on the structure, distribution, and function of α-synuclein, and its interactions with PD. We also summarize the clinic applications of α-synuclein, which suggest its use as a biomarker, and the latest progress in α-synuclein therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Lewy Bodies
/
Neurodegenerative Diseases
/
Alpha-Synuclein
/
Dopaminergic Neurons
/
Alzheimer Disease
Language:
English
Journal:
Journal of Movement Disorders
Year:
2017
Type:
Article
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