Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center
Journal of Pathology and Translational Medicine
;
: 255-263, 2017.
Article
in English
| WPRIM
| ID: wpr-38100
ABSTRACT
BACKGROUND:
Inflammatory myofibroblastic tumor is a histopathologically distinctive neoplasm of children and young adults. According to World Health Organization (WHO) classification, inflammatory myofibroblastic tumor is an intermediate-grade tumor, with potential for recurrence and rare metastasis. There are no definite histopathologic, molecular, or cytogenetic features to predict malignant transformation, recurrence, or metastasis.METHODS:
A 5-year retrospective study of histopathologically diagnosed inflammatory myofibroblastic tumors of various anatomic sites was conducted to correlate anaplastic lymphoma kinase-1 (ALK-1) expression with histological atypia, multicentric origin of tumor, recurrence, and metastasis. Clinical details of all the cases were noted from the clinical work station. Immunohistochemical stains for ALK-1 and other antibodies were performed. Statistical analysis was done using Fisher exact test.RESULTS:
A total of 18 cases of inflammatory myofibroblastic tumors were found during the study period, of which 14 were classical. The female-male ratio was 11 and the mean age was 23.8 years. Histologically atypical (four cases) and multifocal tumors (three cases, multicentric in origin) were noted. Recurrence was noted in 30% of ALK-1 positive and 37.5% of ALK-1 negative cases, whereas metastasis to the lung, liver, and pelvic bone was noted in the ALK-1 positive group only.CONCLUSIONS:
Overall, ALK-1 protein was expressed in 55.6% of inflammatory myofibroblastic tumors. There was no statistically significant correlation between ALK-1 expression, tumor type, recurrence and metastasis. However, ALK-1 immunohistochemistry is a useful diagnostic aid in the appropriate clinical and histomorphologic context.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pelvic Bones
/
Recurrence
/
World Health Organization
/
Tertiary Healthcare
/
Immunohistochemistry
/
Retrospective Studies
/
Classification
/
Cytogenetics
/
Coloring Agents
/
Myofibroblasts
Type of study:
Observational study
Limits:
Child
/
Humans
Language:
English
Journal:
Journal of Pathology and Translational Medicine
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS