Effects of Botulinum Toxin A Injection into Salivary Glands of Patients with Brain Lesion Suffering from Posterior Drooling
Brain & Neurorehabilitation
;
: 121-125, 2011.
Article
in English
| WPRIM
| ID: wpr-38161
ABSTRACT
OBJECTIVE:
The aim of the study was to evaluate the effectiveness of ultrasouond-guided salivary gland injection of botulinum toxin A (BTX-A) for posterior drooling.METHOD:
11 patients with brain lesion (9 cerebral palsy, 1 hypoxic ischemic encephalopathy and 1 mental retardation) with posterior drooling (an initial PDAS score greater than 2) and related pulmonary problems were recruited. Drooling severity was measured at baseline, 4 weeks, 3 months and 6 months after botulinum toxin A injection, by using Teacher Drooling Scale (TDS), Visual Analogue Scales (VAS), Drooling Score System (DSS)-severity, frequency and Posterior Drooling/Aspiration System (PDAS).RESULTS:
The TDS, DSS-severity, DSS-frequency, VAS, PDAS were significantly reduced at 4 weeks and 3 months after BTX-A injection into salivary glands compared to pre-injection (p<0.05). However, there were no significant changes at 6 months compared to pre-injection level.CONCLUSION:
BTX-A injection into salivary glands may improve anterior drooling in patients with brain lesions. Furthermore BTX-A injection into salivary glands may also decrease the posterior drooling which might related to respiratory symptoms in aspiration pneumonia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia, Aspiration
/
Salivary Glands
/
Sialorrhea
/
Sorbitol
/
Stress, Psychological
/
Weights and Measures
/
Botulinum Toxins
/
Brain
/
Tyramine
/
Cerebral Palsy
Limits:
Humans
Language:
English
Journal:
Brain & Neurorehabilitation
Year:
2011
Type:
Article
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