Synthesis and HIV-1 inhibitory activity of natural products isolated from Gnetum parvifolium and their analogues / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1509-15, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-382254
ABSTRACT
Resveratrol, isorhapontigenin and pinosylvin, isolated from Gnetum parvifolium, and their analogues have been synthesized and tested for their inhibitory activity of HIV-1. Natural product 12a and analogues (12d, 12e, 12g) display significant inhibitory activity of HIV-1 replication. Among them, compound 12d (trans-3, 4, 5, 4'-tetrahydroxystilbene) exhibits the most potent anti-HIV-1 activity with an IC50 value of 1.84 micromol x L(-1).
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Type:
Article
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