Sulodexide-induced Hyperkalemia: A Case Report / 대한신장학회지
Korean Journal of Nephrology
;
: 227-229, 2009.
Article
in Korean
| WPRIM
| ID: wpr-38228
ABSTRACT
Sulodexide is composed of two glycosaminoglycans (fast-moving heparin 80%, dermatan sulfate 20%) that are capable of preventing diabetic nephropathy by correcting abnormal glycosaminoglycan metabolism. Considering heparin-like propertyof sulodexide, side effect profiles of sulodexide are expected to be similar with those of heparin. Among those side effects, we remarked on heparin-induced hyperkalemia and hereby report a case of severe hyperkalemia during the use of sulodexide. A 52-year-old man with diabetic nephroapthy and hypertension was admitted to our hospital because of severe hyperkalemia up to 7.5 meq/L. His clinical condition was stable and medications including losartan and furosemide had not been changed for last 6 months except the addition of sulodexide, which was started 30 days prior to admission. Despite intensive use of Kayexalate and immediate discontinuation of losartan, hyperkalemia aggravated up to 8.0 meq/L. After recognition of possible sulodexide-induced hyperkalemia, sulodexide was discontinued, which resulted in rapid correction of hyperkalemia. In view of the above discussed clinical consideration, we suspect sulodexide as a major cause of hyperkalmia and report this case with a review of literature.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polystyrenes
/
Heparin
/
Losartan
/
Dermatan Sulfate
/
Diabetic Nephropathies
/
Furosemide
/
Glycosaminoglycans
/
Hyperkalemia
/
Hypertension
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
2009
Type:
Article
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