Prevalence of virulence genes in Streptococcus pneumoniae strains isolated from clinical patients / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
; (12): 177-180, 2009.
Article
in Zh
| WPRIM
| ID: wpr-383565
Responsible library:
WPRO
ABSTRACT
Objective To investigate the prevalence of virulence genes(ply, pspA, nanA, lytA, psaA) among Streptococcus pneumoniae recently isolated from clinical patients. Methods The 133 strains were isolated from patients in three teaching hospitals in Chongqing from 2006 to 2008. Polymerase chain reaction was used to screen for virulence genes (ply, pspA, nanA, lytA, psaA). Results The positive rate of lytA, psaA, ply, nanA and pspA in 133 clinical isolates were 94.7%, 85.0%, 82.7%, 84. 2% and 60.2%, respectively. The positive rates of the lytA, psaA, ply, nanA and pspA genes in 87 common serotypes isolates was 100%, 87.4%, 86.2%, 89.7%, 67.8%, respectively. Conclusion The total positive rates of five virulence genes in the 133 clinical strains were high. The positive rates of five genes in the com-mon serotypes isolates were higher than those in the no-common serotypes. These genes are important virulence genes of Streptococcus pneumoniae. They could be candidates for protein vaccine of Streptococcus pneumoniae.
Full text:
1
Index:
WPRIM
Type of study:
Prevalence_studies
/
Risk_factors_studies
Language:
Zh
Journal:
Chinese Journal of Microbiology and Immunology
Year:
2009
Type:
Article