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Expression of protein in cervical minimal deviation adenocarcinoma / 肿瘤研究与临床
Cancer Research and Clinic ; (6): 237-240, 2008.
Article in Chinese | WPRIM | ID: wpr-383888
ABSTRACT
Objective To study the valuable index for the diagnosis of cervical minimal deviation adenocarcinoma(MDA).Methods Immunohistochemical EnVisionTM two-step method was used to evaluate the expression of CEA,Ki-67,p16,MUC6,MUC5AC,ER,PR,α-SMA in 9 samples of MDA.12 normal cervical gland tissues and 21 other types of cervical adenocarcinomas were as controls. Results The expression of CEA,MUC6,α-SMA protein in MDA(positive ratio orderly 66.67%,77.78%,88.89%)was higher than that of normal cervical gland(0,8.33%).The average Ki-67 labeling index in MDA(21.03±5.46)was also higher than that of the normal group(0.12±0.08).But as to the expression of ER and PR,the former was lower than the latter.All the differences had statistical significance (P<0.05).The expression of p16,MUC5AC had no statistical significance between the two groups(P>0.1).The ratio of positive expression of MUC6 protein in MDA(77.78%)was higher than that of the other types of adenocarcinomas(14.29%),with the expression of p16(11.11%)lower than the latter(71.43%).All the differences had statistical significance(P<0.01).The expression of CEA,Ki-67,MUC5AC,ER,PR,α-SMA had no statistical significance between the two groups(P>0.05).Conclusion Immunohistochemical positive detection of CEA,Ki-67,MUC6,α-SMA perhaps make for the diagnosis of cervical MDA.The absence of ER,PR of gland cells also support MDA.Overexpression of p16 may play an impo~ant role on the occurrence and the development of some usual adenocarcinoma of cervix,but perhaps not in MDA.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Cancer Research and Clinic Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Cancer Research and Clinic Year: 2008 Type: Article