Research advances in relationship between methyl-CpG binding domain proteins and the repression of tumor repressor genes / 肿瘤研究与临床

ABSTRACT

Many genetic events have been described to be involved in the development of tumor,but a lot of recent researches proved that epigenic events also played an important role in it.DNA methylation is one of the common modification of epigenic events,the binding of methyl-CpG binding domain proteins has been shown to lead to transcriptional repression of many tumor repressor genes.