The influence of cold provocation on retinal light sensitivity of patients with primary open-angle glaucoma / 中华眼底病杂志

ABSTRACT

Objective　To evaluate the effects of cold provocation on optic dise blood flow and retinal light sensitivity of primary open-angle glaucoma (POAG) patients,and explore the relationship between the changes of optic disc blood flow and retinal light sensitivity.　Methods　A total 33 POAG patients　(33　eyes) and 13 normal controls　(13　eyes)　were tested by using the Heidelberg retinal flowmetry (HRF) and Topcon automatic perimeter,and the optic disc blood flow and retinal light sensitivity of POAG patients and normal controls were measured at normal conditions and after cold provocation.　Results　The mean optic disc blood flow,volume and the mean retinal light sensitivity of POAG patients decreased significantly (P＜0.05)　after cold provocation.There was a linear and significant relationship between the decrease of mean optic disc blood flow and mean retinal light sensitivity of POAG patients (r=0.615,P＜0.001).The optic disc blood flow of POAG patients with a history of migraine were more likely to reduce in response to cold provocation and reduced much more than those without such history (P＜0.05).　Conclusion　Cold provocation can significantly reduce both the optic disc blood flow and retinal light sensitivity in POAG patients.A close correlation was found between the amount of mean optic disc blood flow decrease and the volume of mean retinal light sensitivity decline.