Clinical efficacy of bowel obstruction treated by octreotide / 中国医师进修杂志

ABSTRACT

Objective To observe the clinical efficacy of octreotide for treatment of bowel obstruction. Methods Ninety-five cases of bowel obstruction treated from January 2007 to July 2010 were divided into study group (48 cases) and control group (47 cases) by random digits table. Patients in control group received the conventional therapy including fasting, gastrointestinal decompression, total parenteral nutrition, sufficient fluid infusion, water-electrolyte and acetic-alkali equilibrium maintenance and infection prevention, while patients in study group received octreotide 0.1 mg by subcutaneous injection on the base of above conventional therapy, the clinical symptomatic relief time, gastrointestinal decompression volume,anus exhaust time, hospitalization time and effective power of both groups were observed and compared.Results The clinical symptomatic relief time, gastrointestinal decompression volume, anus exhaust time and hospitalization time in study group were all significantly lower than those in control group, the differences was statistically significant (P ＜ 0.05); the effective power in study group was 97.9%(47/48),which was significantly higher than that in control group(87.2% ,41/47), the difference was statistically significant(P ＜0.05). There was no obvious adverse reactions occurred, the patients of treatment futility were therapied by surgery later. Conclusion Octreotide used to treat bowel obstruction has a reliable efficacy with low reverse reaction and deserves general application.