Association between polymorphism of X-ray repair cross-complementing group 1 gene and radiation induced injury / 国际肿瘤学杂志

ABSTRACT

X-ray repair cross-complementing group 1 gene ( XRCC1 ) serves as one key DNA repair gene. The polymorphism of XRCC1, resulting in the changes of corresponding amino acid and the effect of DNA repair, may contribute to the radiation injury of malignant tumor patients. Current studies have revealed that single nucleotide polymorphisms of XRCC1 may be involved in the radiation injury for patients with tumor. Nevertheless this correlation remains to be further investigated.