Pigment epithelium-derived factor inhibits high glucose-stimulated transforming growth factor β1,fibronectin, and collagen Ⅳ expressions in human mesangial cells / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 70-71, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-384575
ABSTRACT
The expressions of transforming growth factor β1 (TGF-β1), fibronectin (FN), and collagen Ⅳ in human mesangial cells were augmented with increased concentrations of glucose.Pigment epithelium-derived factor (PEDF) at concentrations of 40-160 nmol/L significantly inhibited TGF-β1 expression in a dose-dependent manner(P<0.01).PEDF at concentrations of 5-40 nmol/L significantly decreased FN and collagen Ⅳ expressions in a dose-dependent manner(P<0.01) ,suggesting that PEDF may play a salutary role in diabetic nephropathy by its antifibrogenic activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2011
Type:
Article
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