A review on the gene of the caudal-type homeobox gene -2 in leukemia / 国际儿科学杂志

ABSTRACT

The gene of the caudal-type homeobox gene -2 ( CDX2), a member of the CDX family, is a principal regulator in the development of embryogenesis and haematogenesis . Recent studies have shown aberrant expression of CDX2 in each subtype of leukemia and its involvement in the genesis, progress and prognosis of leukemia as new gene. CDX2 may be a potential gene maker of leukemia in minimal residual disease detection.Studies also suggested that CDX2 be involved in leukemia by modulating HOX gene. To further investigate the mechanism of CDX2 in leukemia can be of great significance for the prediction of relapse and the individualized and targeted therapy.