Study of dilated cardiomyopathy and phospholamban / 国际儿科学杂志

ABSTRACT

It is discovered that dilated cardiomyopathy (DCM) is not only affected by environmental factors, but also has a significant genetic basis. Phospholamban ( PLN ), one of these related genes, is a prominent regulator of myocardial contractility, It is an important regulatory factor for heart muscle contraction. It can regulate the activity of sarcoplasmic reticulum Ca2+ ATPase ( SERCA2a), and inhibit SERCA2a activity through restricting the Ca2+ flow in myocardial cells. The activity of SERCA2a can be improved by lowering the expression of PLNmRNA, and the affinity of SERCA2a is strengthened, so that the heart's activity is improved.