The prognostic value of KISS1 expression of gastrointestinal stromal tumors / 中华普通外科杂志
Chinese Journal of General Surgery
;
(12): 11-14, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-384657
ABSTRACT
Objective To evaluate KISS1 expression, and its significance in the prognosis of GIST patients. Methods In this study, 137 GIST cases and 73 non-GIST sarcoma cases were evaluated for clinicopathological characteristics and immunohistochemistry for KISS1 antibodies. Result The expression rate of KISS1 was 40.9% (56/137) in GISTs,which was significantly correlated with tumor size, disease extent, cellularity, presence of pseudocapaule, Fletcher's risk stratification and metastatic status after resection (P<0.05). Patients with positive KISS1 expression had significantly worse disease free survival and disease specific survival (P < 0.05 ). Conclusions KISS1 expression was associated with some clinicopathological characteristics as well as malignant behaviors in patients with GISTs. KISS1 might be a predictor in prognosis for GIST patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of General Surgery
Year:
2011
Type:
Article
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