Lipoprotein-associated phospholipase A2:an independent predictor of vascular risk and a novel target for therapy / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
;
(12): 702-705, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-384993
ABSTRACT
Lipoprotein-associated phospholipase A2(Lp-PLA2) can rapidly hydrolize and oxidize the oxidized phosphatidylcholine molecules produced in low density lipoprotein and atherogenic lipoprotein (a),generating the soluble proinflammatory and proapoptotic mediatorslyso-phosphatidylcholine and oxidized free fatty acids.It stimulates aggregation and activation of monocyte-macrophage system and induces apoptosis and damages the removal of dead cells.It plays an important role in the development of lipid necrotic core of atherosclerosis.Lp-PLA2 is not an independent risk marker of coronary artery disease and ischemic stroke,but also plays an important role in the development of atherosclerotic plaques.Selective Lp-PLA2 inhibitor reduces the development of necrotic cores.It may play a role in the stabilization of atherosclerotic plaques.At the same time,it may represent a novel target for the treatment of atherosclerosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Prognostic study
Language:
Chinese
Journal:
International Journal of Cerebrovascular Diseases
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS