Relationship between age and prostate-specific antigen level in middle-aged and aged people in Beijing / 中华老年医学杂志

ABSTRACT

Objective To investigate the age distribution of serum prostate-specific antigen (PSA) in middle-aged and aged people in Beijing. Methods From November 2006 to November 2008, the data of men, who visited Beijing Hospital for routine health examination and received a measurement of serum PSA level, were collected and analyzed retrospectively. The eligible men were classified into various age groups over 10-years interval, and the PSA distributions were analyzed in the groups. Results A total of 11557 men were enrolled in this study. Within the entire cohort, the median PSA level was 0. 89 μg/L. The median PSA levels in each age group were as follows 0. 79 μg/L in 40-49 yrs age group, 0.85 μg/L in 50-59 yrs age group, 1.20 μg/L in 60-69 yrs age group,1.44 μg/L in 70-79 yrs age group and 1.52 μg/L in more than 80 yrs age group. The serum PSA level gradually increased along with age. A rapid increase of PSA level began from 60 yrs age. The percentile of men with PSA ＞4 μg/L were 1.3%, 2.6%, 8.8%, 15.4% and 14.4% according to age category. Conclusions The PSA level is positively correlated with age in middle-aged and aged people in Beijing. Especially from 60 years of age, the percentile of men with abnormal PSA increases dramatically. Our results can guide clinicians to understand the population-based distribution of serum PSA and to screen prostate cancer.