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Unrelated stem cell transplantation after reduced-intensity conditioning plus rituximab for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with CNS involvement / 소아과
Korean Journal of Pediatrics ; : 725-729, 2009.
Article in English | WPRIM | ID: wpr-38547
ABSTRACT
Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) with central nervous system (CNS) involvement is usually fatal unless stem cell transplant (SCT) is offered. However, SCT with conventional intensity conditioning is associated with high transplant-related mortality. We describe our experience with unrelated SCTs after reduced-intensity conditioning (RIC) for patients with EBV-HLH with progressive CNS disease. This approach was associated with minimal toxicities and might be an effective option in patients with EBV-HLH with progressive CNS disease. Moreover, the addition of rituximab to RIC appears to be safe and effective in suppressing EBV in the patients with EBV-HLH.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stem Cells / Central Nervous System / Central Nervous System Diseases / Herpesvirus 4, Human / Transplants / Stem Cell Transplantation / Lymphohistiocytosis, Hemophagocytic / Antibodies, Monoclonal, Murine-Derived / Rituximab Limits: Humans Language: English Journal: Korean Journal of Pediatrics Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stem Cells / Central Nervous System / Central Nervous System Diseases / Herpesvirus 4, Human / Transplants / Stem Cell Transplantation / Lymphohistiocytosis, Hemophagocytic / Antibodies, Monoclonal, Murine-Derived / Rituximab Limits: Humans Language: English Journal: Korean Journal of Pediatrics Year: 2009 Type: Article