Effects of valproic acid on leukemia / 国际肿瘤学杂志

ABSTRACT

As a kind of histone deacetylase inhibitor (HDACJ), valproic acid (VPA) influences the development of leukemia by cell cycle arresting , apoptosis induction, fusion gene repression, homing interference and immune- regulation. The clinical combination of all-trans retinoic acid or DNA methyltransferase inhibitor with VPA has been demonstrated anti-leukemia effects. However, it needs further investigation on the anti-leukemia mechanism of VPA as well as its efficacy and safety in clinical application for leukemia patients.