Research advances on tumor stem cells / 国际肿瘤学杂志

ABSTRACT

Accumulating evidences have demonstrated that there are several markers that can be used to recognize cancer stem cell, such as cell surface marker, enzymatic marker,gene expression marker and some functional markers. Cancer stem cell is characterized by multidrug resistance, enhanced DNA repair and antiapoptotic ability ,and some in vivo niche features that may make cancer cells resistant to conventional therapy.The increasing understanding of aberrantly expressed molecules and signaling pathways in TSC may provide the theoretical foundation for designing of target therapeutic strategies for TSC.