Progress of the transcriptional regulation mechanism of Farnesoid X receptor in the pathogenesis of bile metabolic related diseases / 国际外科学杂志
International Journal of Surgery
;
(12): 777-780, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-385740
ABSTRACT
Farnesoid X receptor(FXR), a member of the metabolic nuclear receptor superfamily, plays key roles in maintaining bile acid and lipid homeostasis.FXR is highly expressed in the entero-hepatic system where it transcriptionally regulates bile acid metabolism, intestinal barrier function and liver regeneration, etc.Loss or down regulation of FXR expression can lead to a lot of diseases, such as cholecystolithiasis, biliary cirrhosis,primary hepatic carcinoma, colon carcinoma, etc.Activation of FXR may protect against or provide a pharmacological target for these diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
International Journal of Surgery
Year:
2010
Type:
Article
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