Efficacies of the Modified Ultrafiltration and Peritoneal Dialysis in Removing Inflammatory Mediators After Pediatric Cardiac Surgery / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
;
: 745-753, 2001.
Article
in Korean
| WPRIM
| ID: wpr-38596
ABSTRACT
BACKGROUND:
Cardiopulmonary bypass induces an acute systemic inflammatory response mediated by complement activation and cytokine release. This response is likely to cause capillary leak syndrome and organ dysfunction in infants. Removing harmful cytokines and complement anaphylatoxins after cardiopulmonary bypass may attenuate this response. This study was conducted to see if the modified ultrafiltration and postoperative peritoneal dialysis can reduce plasma inflammatory mediators in pediatric cardiac surgery. MATERIAL ANDMETHOD:
30 infants (age 1.1 to 12.6 months) who underwent closures of ventricular septal defect using cardiopulmonary bypass (CPB) were enrolled in this study. These patients were divided into three groups; 10 patients selected randomly underwent modified ultrafiltration (Group U), 10 with small body weights (RESULT:
There was no differences in CPB time, aortic cross-clamping time, and lowest temperature during CPB. The effluents of peritoneal dialysis contained significant amount of C3a and IL-6, but there was no definitive decrease of serum concentration of C3a and IL-6. The effluents of modified ultrafiltration had some amount of C3a and negligible IL-6, and there was no decrease of serum concentration of these factors.CONCLUSION:
The effluents of peritoneal dialysis contained significant amount of proinflammatory cytokine, IL-6 and complement, C3a. However this study failed to elucidate the decrease in serum levels of these factors. The modified ultrafiltration also was not able to reduce the serum levels of C3a or IL-6 in our study as well.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Thoracic Surgery
/
Body Weight
/
Complement System Proteins
/
Radioimmunoassay
/
Ultrafiltration
/
Cardiopulmonary Bypass
/
Complement C3a
/
Anaphylatoxins
/
Cytokines
Limits:
Humans
/
Infant
Language:
Korean
Journal:
The Korean Journal of Thoracic and Cardiovascular Surgery
Year:
2001
Type:
Article
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