Expression and clinical significance of CD44v3 and VEGF-C in gastric cancers / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
;
(12): 2740-2742, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-386136
ABSTRACT
Objective To investigate the expression of CD44v3 and VEGF-C in human gastric cancers and the clinical significance. Methods The expression of CD44v3 and VEGF-C was detected by immunohistochemistry SP method in 92 gastric cancer tissues. Results Positive immunohistochemical stain for CD44v3 was identified in 27.2% of gastric cancer tissues. There was no correlation found among the expression of CD44v3 with sex, location,depth of invasion, WHO type, Lauren type as well as distant metastasis (all P > 0. 05 ). The expression of CD44v3 was positively correlated with lymph node metastasis and tumor differentiation( all P < 0. 05 ). Positive immunohistochemical stain for VEGF-C was identified in 48.9% of gastric cancer tissues. There was no correlation found among the expression of VEGF-C with sex,location, tumor differentiation, depth of invasion, WHO type, as well as distant metastasis ( all P > 0. 05 ). The expression of VEGF-C was positively correlated with lymph node metastasis and Lauren type ( all P <0. 05). Cox-Regression reflected that only the lymphatic metastasis situation correlated with the life ratio( P =0. 015). Conclusion The expression of CD44v3 and VEGF-C could suggest the progression and metastatic potential value of gastric cancer,but didnt correlate with the life ratio. There was no cooperation between CD44v3 and VEGF-C in promoting gastric cancer metastasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Primary Medicine and Pharmacy
Year:
2010
Type:
Article
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