Insulin promotes rhesus retinal vascular endothelial cells angiogenesis via VEGF-A/VEGFR2 pathway / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 891-893, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-386315
ABSTRACT
Rhesus retinal vascular endothelial cell line RF/6A cells were treated with human insulin. Cell proliferation, migration, and lumen formation, as well as the expressions of vascular endothelial growth factor-A ( VEGF-A ), VEGF-A receptors, and phosphorylated receptors were measured. Insulin promoted RF/6A cell proliferation, migration, and lumen formation ( all P<0. 01 ). Insulin increased the expression of VEGF-A mRNA and improved its protein activity ( all P<0. 05 ), and promoted the expression of VEGFR2 mRNA and its phosphorylation ( both P<0. 01 ). There was no significant difference in the expression of VEGFR1 mRNA among the groups ( P>0. 05 ).
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2010
Type:
Article
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