Cellular senescence and cancer / 国际肿瘤学杂志

ABSTRACT

Cellular senescence is an extremely stable form of cell cycle arrest and can be induced by DNA damage as well as oncogene activation. Oncogene-induced senescence is considered as an important barrier against the development of cancer.Several recent reports found that oncogene-induced senescence occurs in the early stages of cancer development.A large number of cells enter senescence in premalignant neoplastic lesions but much less cells do so in malignant tunors.So, senescence is a significant characteristic of premalignant tumor cells, therefore may have important diagnostic and/or prognostic values for management of cancer.