The association between heat-shock protein 70-2 gene + 1267A/G polymorphism and coronary heart disease / 中国医师杂志
Journal of Chinese Physician
;
(12): 1194-1197, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-386475
ABSTRACT
Objective To investigate the correlation between heat-shock protein 70-2 (HSP70-2) gene+1267A/G polymorphism and coronary heart disease (CHD) in Han Chinese population. Methods Using the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) , the polymorphism and genotype and allele distribution of HSP70-2 gene + 1267A/G in 185 CHD patients and 149 controls were analyzed. Results The HSP70-2 gene + 1267A/G polymorphism was found in this study population.The distribution of HSP70-2 genotypes was in Hardy-Weinberg equilibrium. The frequency of G allele in CHD group was significantly higher than that in control (61.89% vs51.68%, P < 0. 01). After multiple logistic regression analysis, HSP70-2 gene (GG + AG) genotype was an independent risk factor of coronary heart disease. Conclusion HSP70-2 gene + 1267A/G polymorphism was associated with CHD risk of Han Chinese population, the G allele might serve as a genetic risk factor of coronary heart disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Risk factors
Language:
Chinese
Journal:
Journal of Chinese Physician
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS