Effect of tolazoline on persistent hypoxemia in severe hyaline membrane disease
Yonsei Medical Journal
;
: 156-162, 1990.
Article
in English
| WPRIM
| ID: wpr-38648
ABSTRACT
Ten critically-ill preterm infants with severe hyaline membrane disease received tolazoline because of persistent hypoxemia refractory to the administration of 100% oxygen and mechanical ventilation. Seven infants (70%) responded immediately with an increase in PaO2 greater than or equal to 20 mmHg in the umbilical arterial gas within 60 minutes after bolus infusion (1 to 2 mg/kg) of tolazoline. Twenty-four hours later after the tolazoline infusion, the FiO2 had been decreased from 1.0 to a mean of 0.82 +/- 0.16, and the MAP from 16.5 +/- 1.8 to 15.6 +/- 4.5 cm H2O. Four of 7 infants (57%) who had an immediate response survived, whereas none survived out of 3 infants who failed to respond initially. Three infants experienced relatively severe complications possibly related to tolazoline. There appears to be a place for the use of tolazoline in a severely hypoxemic infant with hyaline membrane disease who is being ventilated, and in whom arterial oxygenation cannot be improved by a further increase in the inspired oxygen concentration or by an alteration of ventilator settings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tolazoline
/
Infusions, Intravenous
/
Hyaline Membrane Disease
/
Hypoxia
Limits:
Humans
/
Infant
/
Infant, Newborn
Language:
English
Journal:
Yonsei Medical Journal
Year:
1990
Type:
Article
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