The effects of Ozagrel sodium on plasma levels of brain natriuretic peptide and IL-18 in patients with unstable angina pectoris / 中国基层医药

ABSTRACT

Objective To study the treatment effect of Ozagrel sodiumin on plasma levels of BNP and IL-18in patients with unstable angina pectoris. Methods 106 patients with unstable angina pectoris were treated randomly with routine therapy(n =40) and with routine therapy plus Ozagrel sodium(n = 66) for 2 weeks. Before and after 2weeks of the therapy,the changes of BNP and IL-18 were measured. Results After 2 weeks,the levels of BNP and IL-18 in routine therapy group and Ozagrel sodium treatment group were decreased than those before treatment,but after 2 weeks of the therapy,BNP and IL-18 were significantly decreased in candesartan treatment group compared with those in the control group(P ＜0. 05). Conclusion On the basic of general treatment,using the Ozagrel sodium could lower the serum levels of BNP and IL-18 in UAP,and improve stability of atherosclerosis plaque.