The interaction analysis of genetic and behavioral factors on the occurrence of acute coronary syndrome / 中华行为医学与脑科学杂志

ABSTRACT

Objective To explore the the interaction analysis of genetic and behavioral factors on the occurrence of acute coronary syndrome. Methods This study consisted of 134 subjects between June 2009 and Dec.2009 from affiliated hospital of Jining Medical University, All subjects underwented selective coronary angiography or coronary artery CT. Coronary artery disease based on the results of coronary angiography or coronary artery CT that at least one coronary artery diameter reduction of more than 50% and fulfilled the diagnostic criteria of ACC/AHA. 84 patients with acute coronary syndrome and 50 controls, and general informations, current disease history,past medical history, related be havioral factors were collected. DNA was extracted from acute coronary syndromepatients and healthy control subjects, stored in -20 ℃. The genotype of CFH Y402H was detected by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) methods in acute coronary syndrome patients and controls. PCR amplification products was verificated by electrophoresis on agarose gel. Deviation of genotype distribution form Hardy-Weinberg equilibrium was assessed using x2 test in each group. Univariate and multivariate conditional logistic analyses were conducted in the end. Results The results showed that smoking history (P=0.000, OR =4.894,OR 95% CI2.537 ～9.441 ), alcohol drinking history(P= 0.008,OR =2.879,OR 95% CI 1.499 ～ 5.528 ), hypertension (P = 0.000, OR = 4.222, OR 95% CI 2.195 ～ 8.123), sports activities (P =0.002,OR =0.333, OR 95% CI0.188 ～ 0.589 ), salt intake (P= 0.006, OR = 0.457, OR 95% CI0.287 ～0.727 ), character(P = 0.000, OR = 0.385, OR 95% CI0.247 ～ 0.600 ) stress of occupations (P = 0.015, OR =2.118, OR 95% CI 1.278 ～ 3.511 ) were associated with acute coronary syndrome of Northern Chinese Han population. Smoking history(P = 0.010, OR = 6.084, OR 95% CI 1.543 ～ 23.988), hypertension (P= 0.024, OR =2.821, OR 95% CI 1.143 ～ 6.595 ), sports activities (P= 0.004, OR = 0.297, OR 95% CI0.130 ～ 0.678 ), personality(P= 0.011, OR = 0.435, OR 95% CI0.229 ～ 0.829 ) were significantly associated with acute coronary syndrome in multivariate conditional logistic analyses after adjusting other factors. Conclusions Smoking history,hypertension, personality are risk factors of acute coronary syndrome of Northern Chinese Han population. Butsports activities is protective factors.