The reseach advancement of manufacture and identfication of animal models of cerebral palsy / 国际儿科学杂志

ABSTRACT

Cerebral palsy(CP)is one of the main diseases which induce the invalids of children nervous system.The pathogenesis of CP iS fairly complex,which correlates with many factors.At present,there is no one kind of animal odel of CP that can be received by the public.To solve this problem,this review summarizes the most up-to-date three models which relate to the pathogenesis,ischemia and hypoxia model,infection model and hyperbilirubin model,and compares their different validities,eventually brings forward the common effective criterions to identiticare different models.Among these three models,the ischemia and hypoxia model is the most popular application and research objection,the two others are sprouting on their way waiting further develpoment.