GAS/CCK-2R and function of its antagonists in treatment of the pancreatic cancer / 国际外科学杂志
International Journal of Surgery
;
(12): 609-612, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-387350
ABSTRACT
Studies in recent years revel that there is a close relationship between gastrin/cholecystokinin-2 receptors (GAS/CCK-2R) and pancreatic cancer. CCK-2R is widely distributed in human body, but not in normal exocrine pancreas. However, CCK-2R is abnormally expressed in pancreatic carcinoma. The abnormal expression of CCK-2R in pancreatic tissues leads to the abnormal protein expression and activation, changes in acinar cells' morphology and phenotype and an increase in the sensitivity to carcinogenic substances. And some GAS/CCK-2R antagonists can be used for the early and late treatment of pancreatic cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Surgery
Year:
2010
Type:
Article
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