Anti-cancer effects of immunotoxins and its improvement strategy / 国际肿瘤学杂志

ABSTRACT

Immunotoxin is composed of chemical crosslinked mixture of specific monoclonal antibody or growth factor and toxin. Immunotoxin exerts its anti-cancer effects through inhibiting protein synthesis in cancer cells and promoting cancer cell apoptosis. Although immunotoxin is characterized by high toxicity and specificity which may provide remarkable potential in tumor therapy compared with traditional anti-cancer drugs, there are a lot of limitations for its clinical application.