Glycogen synthase kinase-3 and tumorigenesis / 国际肿瘤学杂志

ABSTRACT

It has recently been demonstrated that Glycogen synthase kinase-3β (GSK-3β) plays an important role in tumorigenesis through its regulation of tumor cell growth via a variety of mechanisms. In some tumors, activation of GSK-3β inhibits the growth of tumor cells whereas in other tumors, GSK-3β promotes tumor cells growth, meanwhile, GSK-3β may also regulate sensitivity of chemotherapy drugs to tumor cells,thus GSK-3β is likely to become a novel target for tumor therapy.