Indoleamine 2,3-dioxygenase and immune tolerance in the gallbladder carcinoma / 国际外科学杂志
International Journal of Surgery
; (12): 476-479, 2010.
Article
in Zh
| WPRIM
| ID: wpr-388239
Responsible library:
WPRO
ABSTRACT
Indoleamine 2,3-dioxygenase(IDO)is the rate-limiting enzyme in the catabolism of trypto-phan along the kynurenine pathway.Over expression of IDO is one of the reasons which are responsible for immune tolerance of tumor.IDO also affects the effects of the vaccine of the dendritic cell in the tumor therapy.Lipopolysaccharide(LPS),cytokines and so on can regulate the expression of IDO via different regulating mechanisms.IDO participates in the local immune tolerance of tumor by three kinds of mechanisms.Further research on this immunological regulatory mechanism will be significant for tumor immunotherapy.
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Index:
WPRIM
Language:
Zh
Journal:
International Journal of Surgery
Year:
2010
Type:
Article