Melanocortin 4 receptor and children obesity / 国际儿科学杂志

ABSTRACT

Mutations in the melanocortin 4 receptor (MC4R) represent the most common known cause of monogenic human obesity.MC4R is a family of the five melanocortin receptors.It is an exon lying on chromosome 18.Studies have proved that there is a closed relationship between MC4R and weight regulation.MC4R mutation can result in severer adolescent obesity.