Correlation of beta-catenin and p53 Protein Expression with Clinico-pathologic Characteristics of Colorectal Cancer
Journal of the Korean Society of Coloproctology
;
: 311-316, 2002.
Article
in Korean
| WPRIM
| ID: wpr-38849
ABSTRACT
PURPOSE:
Both the beta-catenin and p53 play a crucial role in the process of colon carcinogenesis. The expression of beta-catenin and/or p53 has been reported to be associated with pathologic features of tumor and prognosis of patients. In addition, several recent studies have suggested a close biological association between p53 expression and nuclear beta-catenin level. We analyzed the pathologic variables and p53 expression according to the intra-nuclear beta-catenin expression in colon cancer to make such assumptions more clear since they are still controversial issues.METHODS:
The expressions of beta-catenin, p53 and Ki-67 protein in colon cancer were determined by immunohistochemical staining. The relationship between these protein expressions and tumor characteristics was statistically analyzed.RESULTS:
The intra-nuclear beta-catenin accumulation was not associated with any of the pathological variables including lymph node metastasis and tumor differentiation, but it was correlated with higher level of Ki-67 proliferation index (P=0.006) and negative staining of p53 (P=0.015). Positive p53 staining was significantly associated with lymph node metastasis (P=0.006), lymphatic invasion (P=0.03) and venous invasion (P=0.02).CONCLUSION:
These results support the suggestion that intra-nuclear accumulation of beta-catenin may regulate the p53 activity in colorectal cancer. In addition, positive staining of p53 may be used as a valuable prognostic indicator since it was strongly associated with lymph node metastasis, lymphatic and venous invasion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Colorectal Neoplasms
/
Negative Staining
/
Colon
/
Colonic Neoplasms
/
Beta Catenin
/
Carcinogenesis
/
Lymph Nodes
/
Lymphatic Metastasis
/
Neoplasm Metastasis
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Coloproctology
Year:
2002
Type:
Article
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