Poly(ADP-ribose) polymerase 1 and its inhibitors in tumor treatment / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 263-265, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-388520
ABSTRACT
Poly( ADP-ribose) polymerase 1 (PARP-1) plays an essential role in DNA repair and maintenance of homeostasis and genome stability. Increased PARP-1 activity has been reported in various forms of cancer. Thus the absence of PARP-1 or the use of its inhibitors depresses DNA repair function, sensitizes cancer cells to DNA damage and enhances the therapeutic effect of radio-or chemotherapy. PARP-1 is potentially a therapeutic target of malignant tumors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2010
Type:
Article
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