Experimental research on anti-fibrosis effect of Fuzheng-Liqi mixture in rat hepatic fobrosis induced by alcohol / 国际中医中药杂志

ABSTRACT

Objective To explore the mechanisms and preventive effects of Fuzheng-Liqi mixture on alcoholic hepatic fibrosis. Methods 48 male SD rats were randomly divided into four groups normal group, model group, Compound Salviae Miltiorrhizae (CSM) group and Fuzheng-Liqi mixture (FLM) group. Alcohol was poured into stomach of the rats for 16 weeks to induce hepatic fibrosis. At the same time, CSM and FLM were given to each group. The rats were killed after 16 weeks. Histomorphylogic structure of the liver tissues was observed under optical microscope; the levels of MDA and SOD in rounded by thick cords of collagen fibers, which extended from the portal areas and central veins. Obvious cloudy swelling could be seen in hepatocytes. Fatty degeneration was extensive, and some with necroses fiber septa were infiltrated by a great number of cells such as monocytes, lymphocytes, eosinophilic granulocytes, fibroblasts, and so on. Compared with the model group, the destructions were slighter, proliferations of collagen fibers were also fewer, fiber cords were more loosened and comparison of collagen area in Masson staining The collagen area in the CSM group and FLM group were less than the model of serum SOD was increased obviously in the FLM group (P＜0.05). Conclusion The mechanism of Fuzheng-Liqi mixture in anti-fibrosis effects may be correlated with its anti-lipid peroxidation.