Continuous renal replacement therapy in multiple organ dysfunction syndrome / 中国医师进修杂志

ABSTRACT

Objective To observe the efficacy of continuous renal replacement therapy (CRRT) treatment in multiple organ dysfunction syndrome (MODS),and explore its application value.Methods Forty-six cases of MODS were treated with CRRT.Blood gas analysis,toxin removal,electrolyte and APACHE Ⅱ score was observed before and after treatment.Results The APACHE Ⅱ score in the beginning of treatment was (20.8 ±4.4) scores,31 cases had clinical cure,and APACHE Ⅱ score was (13.6 ±4.9)scores,15 cases died.In patients of survival,blood pressure,blood gas analysis,electrolytes,toxin removal improved gradually,and the difference had statistical significance before and after treatment.In 8 cases withshock before treatment who need drugs to maintain blood pressure,after treatment 6 cases withdrew drugs gradually.In the course of treatment,heart function was stable in patients who had heart failure.Four cases had pulmonary infection-induced MODS.In the process of the treatment internal environment was stable,and urine after treatment improved in different degrees.Two cases died of drug-resistant pathogens ultimately.Conclusions CRRT is an effective method in the treatment of MODS patients.CRRT can effectively clear the metabolites and inflammatory mediators,and rebuild the immune homeostasis of the body.