Correlation of plasma PAC-1 and CD62P levels with diabetic nephropathy in type 2 diabetes mellitus / 中华全科医师杂志
Chinese Journal of General Practitioners
; (6): 495-497, 2010.
Article
in Zh
| WPRIM
| ID: wpr-388859
Responsible library:
WPRO
ABSTRACT
Three hundred and thirty eight patients with type 2 diabetes mellitus( DM) admitted from January 2006 to June 2009 and 50 healthy subjects (control group) were enrolled in the study. Platelet glycoprotein PAC-1 and CD62P levels were measured in both groups. Compared with control group, plasma PAC-1 and CD62P levels of DM patients increased significantly (P <0.01). Patients were divided into three groups according to their urinary albumin excretion rate ( UAER) . PAC-1 and CD62P levels in macroalbuminuria group (UAER≥200μg/min) were significantly higher than those in normoalbuminuria group( UAER <20μg/min) and microalbuminuria group (20μg/min≤UAER < 200μg/min) (both P< 0.05). The results indicate that plasma levels of PAC-1 and CD62P, which reflect platelet activation, are the independent risk factors for diabetic nephropathy.
Full text:
1
Index:
WPRIM
Type of study:
Risk_factors_studies
Language:
Zh
Journal:
Chinese Journal of General Practitioners
Year:
2010
Type:
Article