Effect of IL-6 and TNF-a in the Cervical Spondylotic Myelopathy / 中国基层医药

ABSTRACT

Objective To measure the levels of interleukin-6 (IL-6) and tumor necrosis factor-a( TNF-a) in the cervical intervertebral disk of patients with cervical spondylotic myelopathy ( CSM) ,study the role of IL-6 and TNF-a in the pathogenesis of CSM.Methods 40 degenerative cervical vertebral disk tissues were collected from CSM cases;20 normal tissues of vertebral disk were taken as control.The contents of IL-6 and TNF-a were detected by ELISA.Results The contents of IL-6 and TNF-a in disk of CSM sufferers increased significantly compared with the control group (P<0.01).Conclusion The results of the present study indicated that IL-6 and TNF-a may be involved in the pathogenesis of CSM.