Relationship between vascular endothelial function and high-sensitivity C reactive protein ,soluble intercellular adhesion molecule-1 in patients with essential hypertension / 中国医师进修杂志

ABSTRACT

Objective To study the relationship between endothelial diastolic factor[calcitoningene-related peptide(CGRP),prostaglandin I2(PGI2)],endothelial contract factor[endothelin(ET)-1,thromboxane B2(TXB2)],the serum high-sensitivity C reactive protein(ha-CRP)and soluble intercellular adhesion molecule(sICAM)-1 level in patients with essential hypertension(EH).Methods Forty-two EH patienm(EH group)received no medication were randomly divided into 3 subgroups(class 1,class 2,class 3),and 40 healthy volunteers were enrolled as control group.The levels of CGRP,6-keto-PGF1α,ET-1,TXB2 were determined by the method of radioimmunity,and the serum level of sICAM-1 Was detected by ELISA while the level of hs-CRP was detected by the method of Laser nephelometry.Results The levels of ET-1,TXB2,ha-CRP,sICAM-1 were higher,whereas the levels of CGRP,6-keto-PGF1α were lower in EH group[(102.23±17.60)ng/L,(102.25±24.61)ng/L,(14.58±2.16)mg/L,(224.89±49.28)μg/L,(28.95±9.68)ng/L,(54.26±18.96)ng/L,respectively]than those in control group[(50.81±6.54)ng/L,(76.11 ±20.23)ng/L,(2.33±1.21)mg/L,(112.51±22.47)μg/L,(63.12±16.74)ng/L,(89.54±21.4s)ng/L,respectively](P<0.01).the levels of ET-1,TXB2,hs-CBP,sICAM-1 increased,whiled the CGRP,6-keto-PGF1α levels decreased in order in class 1,class 2 and class 3,and there were statistical differences between any two of the classes(P<0.05 or<0.01).The levels of hs-CRP and sICAM-1 were positively correlated with ET-1, TXB2,but negatively correlated with CGRP,6-keto-PGF1α in EH group.Conclusions The changes of ET-1,TXB2,hs-CBP,sICAM-1 have a close relation with the levels of blood pressure in EH patients,and there are correlations between vascular endothelial function and inflammation factor.These suggest that they may be involved in the genesis and development of hypertension.