Effect of troglitazone on insulin secretion in pancreatic β-cells and its mechanism / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
; (12): 493-495, 2010.
Article
in Zh
| WPRIM
| ID: wpr-389389
Responsible library:
WPRO
ABSTRACT
The effect of troglitazone on glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells and its mechanism were investigated.10 μmol/L troglitazone had no effect on basal insulin secretion,but significantly decreased GSIS and stimulated AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) phosphorylations (all P<0.01).These reactions were completely reversed by AMPK inhibitor compound C,suggesting that the troglitazone acutely inhibits insulin secretion via stimulating AMPK activity in beta cells.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2010
Type:
Article