The present understanding of serine proteinase inhibitor-9 / 国际外科学杂志
International Journal of Surgery
;
(12): 404-407, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-389410
ABSTRACT
Serine proteinase inhibitor9(P1-9),a charac-teristic member of serpins,has been identified as the only inhibitor of granzyme B(GrB).Accumulated evidence suggested that PI-9 inhibits GrB-induced apoptosis by blocking DNA fragmentation of target cell.Physiologically,PI-9 could protect cytotoxic lymphocytes from committing autolysis or fratricide,and play an important role in facilitating immunologic tolerance of immune-privileged sites.In addition,evidences in recent years suggest that PI-9 Was also involved in vailous pathologic processes,such as inflammation,trans plantation and immune tolerance of tumor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
International Journal of Surgery
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS