Association study between the genetic polymorphism of 15 STR loci and the crime of rape / 中华行为医学与脑科学杂志

ABSTRACT

Objective To investigate the relationship between rapists and related allele genes based on the analysis of 15 short tandem repeats (STRs) loci genetic polymorphism. Methods The method of Genome-wide scan was being used. Buccal swab samples of 129 rapists and 156 random populations were collected and PCR compound amplification was carried out with the aid of AmpFISTR Identifiler system. Then the products were subjected to electrophoresis and gene detection with AB13100 type gene analysis system so as to calculate and compare the alleles of 15 STRs gene frequency in the two groups. Results All the 15 STRs loci allele gene frequency in rapists and random population was found to coincide with Hardy-Weinberg law(P>0. 05). Allele 28 of D21S11 (rapists 1.55% ,control group5. 13%) ,allele22 of FGA(rapists24.03% ,control group16.99%),allele23 of FGA(rapists 17.05% ,control group26.28%) ,allele 10 of TH01(rapists1.16% ,control group4.17%) ,allele 8 of TPOX(rapists55.77% ,control group63.77%),allele 12 of TPOX(rapists4.26% ,control group 1.28%) were different between the two groups (P< 0.05) .while it is no differ significantly in other STRs loci allele gene(P >0.05). Conclusion Allele 28 of D21 S11,allele 22 and 23 of FGA, allele 10 of TH01, allele 8 and 12 of TPOX may be associated with the violent crime of rape. It is suggested that there are existing sensitive or resistance genes about the violent crime of rape in chromosome 2,4,11,21.