Inhibiting NF-κB activity down-regulates angiotensinogen expression level in cultured rat mesangial cells / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 411-412, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-389640
ABSTRACT
The angiotensinogen(AGT) expression and angiotensin Ⅱ (AngⅡ ) secretion levels in cultured SD rat mesangial cells were determined. High glucose up-regulated AGT mRNA(0. 29±0.07 vs 0. 20±0. 05,P< 0.05)and protein(0.66±0.23 vs 0.37±0. 15,P<0.05) expression and Ang Ⅱ secretion [(9.85±2.08 vs 7.50± 1. 51) pg/ml,P<0. 05]levels, which were down-regulated by pyrrolidine dithiocarbamate( PDTC) treatment via inhibiting NF-κB activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS