Different influences of pre-and/or postnatal hypoxia on thyroid hormones of newborns / 中国小儿急救医学

ABSTRACT

Objective To investigate the different influences of pre-and/or postnatal hypoxia on the thyroid function of newborns. Methods Newborn infants of fetal hypoxia and/or birth asphyxia diagnosed and treated in pediatric department of Tianjin Medical University Genera] Hospital during last 5 years ,were assigned into intrauterine distress group (group B,n =87) ,birth asphyxia group (group C,n =36) and both of birth asphyxia and intrauterine distress group (group D,n = 75 ). Normal neonates born during the same period served as control group( group A,n =30). Blood concentrations of T3 ,T4 and TSH were detected by radioimmunoassay. Results The serum levels of T3 ,T4 and TSH in A,B,C,and D groups were (0. 86±0. 22) μg/L, (0. 62±0.21)μg/L,(0. 46±0. 19)μg/L,(0. 54±0. 19)μg/L; (125. 13±36.37)μg/L, (107.46±32.21)μg/L,(74.60±26.52)μg/L, (102.23±30.29) μg/L; (6.28±1.96) μg/L, (4.91±1.69) mIU/L, (8.66±2. 00) mIU/L, (5. 64±1.17 mIU/L). There were significant differences among the 4 groups ( P < 0. 01 ). As compared to A group,the serum T3 and T4 concentrations of B ,C and D groups were significantly decreased (P <0. 01 ,P <0. 05 ). No difference of TSH concentrations was found between A and D groups( ( P > 0. 05),but there was significant decrease in B group and significant increase in C group( P <0. 01 ). Conclusion Preand postnatal hypoxia results in decreases of T3 and T4 values,it is likely that newborns of intrauterine distress have decreased TSH, whereas those of birth asphyxia have increased TSH.