Effect of glucose on hormone sensitive lipase in NTT-1 cell / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 235-237, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-390268
ABSTRACT
NIT-1 cells were exposed to various concentrations of glucose for 24,48,and 72 hours.The content of triglyceride in NIT-1 cells increased in dose-and time-dependent manners (P < 0.05).Long-term exposure of NIT-1 cells to high glucose concentrations caused an inverse "v"-like induction of HSL mRNA and protein expressions,which increased from beginning,and then decreased,along with similar changes of lipolysis.These results suggest that the adaptation of HSL may play an important role in regulating the intracellular triglyceride pool and the development of glucolipotoxicity in pancreatic β cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2010
Type:
Article
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