Your browser doesn't support javascript.
loading
Association Between Toll-Like Receptors/CD14 Gene Polymorphisms and Inflammatory Bowel Disease in Korean Population
Journal of Korean Medical Science ; : 72-77, 2012.
Article in English | WPRIM | ID: wpr-39064
ABSTRACT
The innate immune response in patients who develop inflammatory bowel disease (IBD) may be abnormal. However, the exact role of Toll-like receptors (TLRs) / CD14 gene in the pathogenesis of IBD has not been fully elucidated. We aimed to investigate the association between polymorphisms of TLR1, 2, 4, 6, and CD14 gene and susceptibility to IBD in Korean population. A total 144 patients of IBD (99 patients with ulcerative colitis, 45 patients with Crohn's disease) and 178 healthy controls were enrolled. Using a PCR-RFLP, we evaluated mutations of TLR1 (Arg80Thr), TLR2 (Arg753Gln and Arg677Trp), TLR4 (Asp299Gly and Thr399Ile), TLR6 (Ser249Pro) genes and the -159 C/T promoter polymorphism of CD14 gene. No TLR polymorphisms were detected in Korean subjects. T allele and TT genotype frequencies of CD14 gene were significantly higher in IBD patients than in healthy controls. In subgroup analysis, T allelic frequency was higher in pancolitis phenotype of ulcerative colitis. In Korean population, the promoter polymorphism at -159 C/T of the CD14 gene is positively associated with IBD, both ulcerative colitis and Crohn's disease.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenotype / Inflammatory Bowel Diseases / Colitis, Ulcerative / Crohn Disease / Promoter Regions, Genetic / Lipopolysaccharide Receptors / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Asian People / Alleles Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Journal of Korean Medical Science Year: 2012 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenotype / Inflammatory Bowel Diseases / Colitis, Ulcerative / Crohn Disease / Promoter Regions, Genetic / Lipopolysaccharide Receptors / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Asian People / Alleles Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Journal of Korean Medical Science Year: 2012 Type: Article