Clinical efficacy of leukotriene receptor antagonists in treatment of chronic cough / 中国综合临床

ABSTRACT

Objective To explore the clinical efficacy of leukotriene receptor antagonists in treatment of chronic cough. Methods Eighty-one patients with chronic cough, defined by the diagnostic protocol of chronic cough, were recruited. The including criteria are complaining cough 8 weeks or longer, age ≥ 14, nonsmoking or had quitted smoking≥4 weeks, not taking ACEI medicine, not complicated with gastroesophageal reflux related cough, upper airway cough syndrome (besides allergic rhinitis), tuberculosis of bronchus and with normal chest X-ray. Those diagnosed as cough variant asthma(CVA),allergic rhinitis (AR),eosinophilic bronchitis(EB),post infectious cough(PIC) were treated with leukotriene 10 mg daily at night. Results The 81 patients includes36 cases of CVA,30 cases of AR,5 cases with EB,10 cases with PIC. After treatment based on diagnosis, cough disappeared in 67 patients, symptoms improved in 12 patients, and 2 patients' cough did not improved. Conclusions Leukotriene receptor antagonists is an aggressive anti-inflammatory therapy, which can release the symptom of cough and is an important medicine in the treatment of chronic cough.